Gene: [17q1/EGFR2] avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 2; oncogene homolog ERBB2 (neuro/glioblastoma derived); protein tyrosine kinase, receptor ERBB2;
COM | On the ERB-like genes see GEM:17q1/THRA. |
FAG | This gene is homologous to epidermal growth factor receptor, which gene is located in Chr 7 (GEM:07p12/EGFR1). Another homologues are mapped to Chr 12q13 (GEM:12q13/EGFR3) and Chr 2q24 (GEM:02q34/EGFR4)." |
MAP | Loci:
GEM:17q112/NF1; GEM:17q1/THRA; FAM:HOXB/17q2; GEM:17q2/NGFR. [1] See GEM:17q112/NF1." |
REF | MOP "Akiyama &:
Science, 232, 1644-1646, 1986 MOP "Bargmann CI &: Nature, 319, 226-230, 1986 PRO,SEQ,EXP,EVO "Coussens L &: Science, 230, 1132-1139, 1985 LOC,FAG "Francke &: Cold Spring Harbor Symp, 51, 855-866, 1986 LOC "Fukushige S &: BBRC, 134, 477-483, 1986a LOC "Fukushige S &: Mol Cell Biol, 6, 955-958, 1986b LOC "Kaneko &: Jpn J Cancer Res, 78, 16-19, 1987 LOC "Popescu NC &: Genomics, 4, N2, 362-366, 1989 PRO,SEQ,EXP,EVO "Semba K &: PNAS, 82, N19, 6497-6501, 1985 EXP,PAT "Slamon DJ &: Science, 244, (12 May), 707-712, 1989 MAG "Xu WM &: PNAS, 85, N22, 8563-8567, 1988 LOC "Yang-Feng TL &: CCG, 40, (HGM8), 784, 1985 |
SWI | SWISSPROT: P04626 |
KEY | onc, mem, recp |
CLA | coding, basic |
LOC | 17 q11.2-12 |
MIM | MIM: 164870 |
EZN | ENZYME: 2.7.1.112 |
Ссылки:
- Протоонкогены: механизмы активации, амплификация участков ДНК
- Трансформация злокачественная с помощью ДНК опухолей
- Векторы: направление к определенным клеткам
- Gene: [HOXB/17q2] homeo box region B, gene cluster on chr 17q2; (HOXB1 HOXB2 HOXB3 HOXB4 HOXB5 HOXB6 HOXB7 HOXB8 HOXB9 HOXB13)
- Онкогенная активация рецепторных протеинкиназ
- Увеличение экспрессии генов рецепторов
- Gene: [17q2/CDC27] cell division cycle 27 (homologous to CDC27 of yeast, bimA of A. Nidulans, nuc2+ of S. pombe);
- ген v-erbB вируса эритробластоза птиц
- ERBB2 ген