Gene: [17q1/THRA] thyroid hormone receptor, alpha; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; [ERBA1 THRA2 ]

FAG

[1] The gene for beta thyroid hormone receptor has been mapped to Chr 3p243 (GEM:03p243/THRB).
[2] On oncogene homolog ERBB1 see GEM:07p12/EGFR1.
[3] On oncogene homolog ERBB2 see GEM:17q1/EGFR2."

EXP

Alpha-1 (SWI:P21205) and alpha-2 (SWI:P10827) receptors are produced by alternative splicing."

MAP

Loci: GEM:17q112/NF1; GEM:17q1/EGFR2; FAM:HOXB/17q2; GEM:17q2/NGFR.
[1] See GEM:17q112/NF1."

HIS

The uncertainty of data on number and localization of THR genes was began with the report of Gosden-1986, where probe ERBA2 (now THRB) was shown to hybridize in situ with two sites on chr 17 - q21.3 and q25, while all consequent studies mapped THRB(ERBA2) to chr 3p. However, Weinberger-1986 demonstrated the existence of about five or six THR genes, of which three (those for beta receptor) being located in chr 3 and the remaining (those for alpha receptor; they are characterized by a longer mRNA, about 5kb) being located in chr 17. In general, this agrees with the original data (Jansson-1983) on the existence of two classes of ERBA(THR) sequences in the human genome, one of the classes having more than one copy."

REF

EXP,MOL,MEB "Bahn &: BBRC, 150, N1, 259-262, 1988
PRO,EXP,FAG "Benbrook D, Pfahl: Science, 238, 788-791, 1987
LOC,CYG,MUT "Dayton AI &: PNAS, 81, 4495-4499, 1984
PRO,EXP,FAG "Jansson M &: EMBO J, 2, N4, 561-565, 1983
LOC,PRO "Jhanwar SC &: Somat Cell Mol Genet, 11, N1, 99-102, 1985
SEQ "Laudet V &: NAR, 19, 1105-1112, 1991
LOC,PRO "Mittelman F &: Cancer Genet Cytogenet, 22, 95-98, 1986
SEQ "Miyajima N &: Cell, 57, 31-39, 1989
SEQ "Nakai A &: Mol Endocrinol, 2, 1087-1092, 1988a
SEQ "Nakai A &: PNAS, 85, 2781-2785, 1988b
EXP,MOL,MEB "Sakurai A &: Mol Endocrinol, 3, 392-399, 1989
MOP "Sap J &: Nature, 324, 635-640, 1986
LOC,PRO "Sheer &: Ann Hum Genet, 49, 167-171, 1985
LOC,CYG,FAG "Spurr NK &: EMBO J, 3, N1, 159-163, 1984
EAG,FAG "Thompson CC &: Science, 237, 1610-1614, 1987
LOC,PRO "van Tuinen P &: Genomics, 1, 374-381, 1987
REV,FAG,EVO "Weinberger C &: Cold Spring Harbor Symp, 51, (Part 2), 759-772, 1986a
SEQ "Weinberger C &: Nature, 324, 641-646, 1986b
MAG,MAF "Xu WM &: CCG, 51, (HGM10), 1111-1112, 1989
MAG,MAF "Xu WM &: PNAS, 85, N22, 8563-8567, 1988

SWI

SWISSPROT: P21205; THA2 P10827

KEY

onc, recp, horm

CLA

coding, basic

LOC

17 q11.2-12

MIM

MIM: 190120

SYN

ERBA1 THRA2

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