Рис. 10 pat
Нуклеотидная (мРНК) и аминокислотная последовательности тирозиназы человека tattgagttcttcaaacattgtagcctctt tatggtctctgagaaataactaccttaaacccataatctttaatacttcctaaactttc ttaataagagaagctctattcctgacactacctctcatttgcaaggtcaaatcatcatt agttttgtagtctattaactgggtttgcttaggtcaggcattattattactaaccttat tgttaatattctaaccataagaattaaactattaatggtgaatagagtttttcacttta acataggcctatcccactggtgggatacgagccaattcgaaagaaaagtcagtcatgtg cttttcagaggatgaaagcttaagataaagactaaaagtgtttgatgctggaggtggga gtggtattatataggtctcagccaagacatgtgataatcactgtagtagtagctggaaa gagaaatctgtgactccaattagccagttcctgcagaccttgtgaggactagaggaaga atg ctc ctg gct gtt ttg tac tgc ctg ctg tgg agt ttc cag acc met leu leu ala val leu tyr cys leu leu trp ser phe gln thr 15 tcc gct ggc cat ttc cct aga gcc tgt gtc tcc tct aag aac ctg ser ala gly his phe pro arg ala cys val ser ser lys asn leu 30 atg gag aag gaa tgc tgt cca ccg tgg agc ggg gac agg agt ccc met glu lys glu cys cys pro pro trp ser gly asp arg ser pro 45 tgt ggc cag ctt tca ggc aga ggt tcc tgt cag aat atc ctt ctg cys gly gln leu ser gly arg gly ser cys gln asn ile leu leu 60 tcc aat gca cca ctt ggg cct caa ttt ccc ttc aca ggg gtg gat ser asn ala pro leu gly pro gln phe pro phe thr gly val asp 75 gac cgg gag tcg tgg cct tcc gtc ttt tat aat agg acc tgc cag asp arg glu ser trp pro ser val phe tyr asn arg thr cys gln 90 tgc tct ggc aac ttc atg gga ttc aac tgt gga aac tgc aag ttt cys ser gly asn phe met gly phe asn cys gly asn cys lys phe 105 ggc ttt tgg gga cca aac tgc aca gag aga cga ctc ttg gtg aga gly phe trp gly pro asn cys thr glu arg arg leu leu val arg 120 aga aac atc ttc gat ttg agt gcc cca gag aag gac aaa ttt ttt arg asn ile phe asp leu ser ala pro glu lys asp lys phe phe 135 gcc tac ctc act tta gca aag cat acc atc agc tca gac tat gtc ala tyr leu thr leu ala lys his thr ile ser ser asp tyr val 150 atc ccc ata ggg acc tat ggc caa atg aaa aat gga tca aca ccc ile pro ile gly thr tyr gly gln met lys asn gly ser thr pro 165 atg ttt aac gac atc aat att tat gac ctc ttt gtc tgg atg cat met phe asn asp ile asn ile tyr asp leu phe val trp met his 180 tat tat gtg tca atg gat gca ctg ctt ggg gga tct gaa atc tgg tyr tyr val ser met asp ala leu leu gly gly ser glu ile trp 195 aga gac att gat ttt gcc cat gaa gca cca gct ttt ctg cct tgg arg asp ile asp phe ala his glu ala pro ala phe leu pro trp 210 cat aga ctc ttc ttg ttg cgg tgg gaa caa gaa atc cag aag ctg his arg leu phe leu leu arg trp glu gln glu ile gln lys leu 225 aca gga gat gaa aac ttc act att cca tat tgg gac tgg cgg gat thr gly asp glu asn phe thr ile pro tyr trp asp trp arg asp 240 gca gaa aag tgt gac att tgc aca gat gag tac atg gga ggt cag ala glu lys cys asp ile cys thr asp glu tyr met gly gly gln 255 cac ccc aca aat cct aac tta ctc agc cca gca tca ttc ttc tcc his pro thr asn pro asn leu leu ser pro ala ser phe phe ser 270 tct tgg cag att gtc tgt agc cga ttg gag gag tac aac agc cat ser trp gln ile val cys ser arg leu glu glu tyr asn ser his 285 cag tct tta tgc aat gga acg ccc gag gga cct tta cgg cgt aat gln ser leu cys asn gly thr pro glu gly pro leu arg arg asn 300 cct gga aac cat gac aaa tcc aga acc cca agg ctc ccc tct tca pro gly asn his asp lys ser arg thr pro arg leu pro ser ser 315 gct gat gta gaa ttt tgc ctg agt ttg acc caa tat gaa tct ggt ala asp val glu phe cys leu ser leu thr gln tyr glu ser gly 330 tcc atg gat aaa gct gcc aat ttc agc ttt aga aat aca ctg gaa ser met asp lys ala ala asn phe ser phe arg asn thr leu glu 345 gga ttt gct agt cca ctt act ggg ata gcg gat gcc tct caa agc gly phe ala ser pro leu thr gly ile ala asp ala ser gln ser 360 agc atg cac aat gcc ttg cac atc tat atg aat gga aca atg tcc ser met his asn ala leu his ile tyr met asn gly thr met ser 375 cag gta cag gga tct gcc aac gat cct atc ttc ctt ctt cac cat gln val gln gly ser ala asn asp pro ile phe leu leu his his 390 gca ttt gtt gac agt att ttt gag cag tgg ctc cga agg cac cgt ala phe val asp ser ile phe glu gln trp leu arg arg his arg 405 cct ctt caa gaa gtt tat cca gaa gcc aat gca ccc att gga cat pro leu gln glu val tyr pro glu ala asn ala pro ile gly his 420 aac cgg gaa tcc tac atg gtt cct ttt ata cca ctg tac aga aat asn arg glu ser tyr met val pro phe ile pro leu tyr arg asn 435 ggt gat ttc ttt att tca tcc aaa gat ctg ggc tat gac tat agc gly asp phe phe ile ser ser lys asp leu gly tyr asp tyr ser 450 tat cta caa gat tca gac cca gac tct ttt caa gac tac att aag tyr leu gln asp ser asp pro asp ser phe gln asp tyr ile lys 465 tcc tat ttg gaa caa gcg agt cgg atc tgg tca tgg ctc ctt ggg ser tyr leu glu gln ala ser arg ile trp ser trp leu leu gly 480 gcg gcg atg gta ggg gcc gtc ctc act gcc ctg ctg gca ggg ctt ala ala met val gly ala val leu thr ala leu leu ala gly leu 495 gtg agc ttg ctg tgt cgt cac aag aga aag cag ctt cct gaa gaa val ser leu leu cys arg his lys arg lys gln leu pro glu gly 510 aag cag cca ctc ctc atg gag aaa gag gat tac cac agc ttg tat lys gln pro leu leu met glu lys glu asp tyr his ser leu tyr 525 cag agc cat tta taa aaggcttaggcaatagagtagggccaaaaagcctgacct gln ser his leu ter cactctaactcaaagtaatgtccaggttcccagagaatatctgctggtatttttctgta aagaccatttgcaaaattgtaacctaatacaaagtgtagccttcttccaactcaggtag aacacacctgtctttgtcttgctgttttcactcagcccttttaacattttcccctaagc ccatatgtctaaggaaaggatgctatttggtaatgaggaactgttatttgtatgtgaat taaagtgctcttatttt