Gene: [01q23/IGHER1A] immunoglobulin E Fc-receptor I, alpha subunit (high affinity); atopy 1? (allergic asthma and hay fever, liability 1); [FCER1A FCE1A ]
|
MOP |
The IgE receptor is assumed to consist of three subunits: alpha (highly glycosylated, located on the outer surface of the cell membrane, MM 50-60 kD) and two intramembrane nonglycosylated components, beta and gamma, with MM 33 and 20 kD, respectively." |
|
FAG |
[1] Two more genes of receptor I for IgE Fc fragment has been
identified: GEM:11q1/IGHER1B; GEM:01q23/IGHER1G.
[2] A gene for receptor II for IgE Fc fragment (GEM:19p133/IGHER2) has been cloned and mapped." |
|
HET |
In addition to this gene, two other markers are mentioned in the MIM and HGM catalogues in connection with atopy diseases, mainly bronchial asthma and hay fever (allergic rhinitis). The genetic and functional relationships between those two markers remain unclear. See also GEM:11q13/IGER and GEM:13q14/IGHEE." |
|
HIS |
The CCM92 gene name: Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide." |
|
REF |
TRC,EXP,EVO,MOU "Liu &: PNAS, 85, N15, 5639-5643, 1988 PRO,COD,SEQ,EVO,HUM,RAT "Shimizu A &: PNAS, 85, N6, 1907-1911, 1988 PRO,LOC,POL,MOL "Tepler I &: AJHG, 45, 761-765, 1989 |
|
KEY |
imm, img, recp, mfd |
|
CLA |
coding, basic |
|
LOC |
01 q23 |
|
MIM |
MIM: 147140 |
|
SYN |
FCER1A FCE1A |
