Gene: [01q23/IGHER1A] immunoglobulin E Fc-receptor I, alpha subunit (high affinity); atopy 1? (allergic asthma and hay fever, liability 1); [FCER1A FCE1A ]

MOP

The IgE receptor is assumed to consist of three subunits: alpha (highly glycosylated, located on the outer surface of the cell membrane, MM 50-60 kD) and two intramembrane nonglycosylated components, beta and gamma, with MM 33 and 20 kD, respectively."

FAG

[1] Two more genes of receptor I for IgE Fc fragment has been identified: GEM:11q1/IGHER1B; GEM:01q23/IGHER1G.
[2] A gene for receptor II for IgE Fc fragment (GEM:19p133/IGHER2) has been cloned and mapped."

HET

In addition to this gene, two other markers are mentioned in the MIM and HGM catalogues in connection with atopy diseases, mainly bronchial asthma and hay fever (allergic rhinitis). The genetic and functional relationships between those two markers remain unclear. See also GEM:11q13/IGER and GEM:13q14/IGHEE."

HIS

The CCM92 gene name: Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide."

REF

TRC,EXP,EVO,MOU "Liu &: PNAS, 85, N15, 5639-5643, 1988
PRO,COD,SEQ,EVO,HUM,RAT "Shimizu A &: PNAS, 85, N6, 1907-1911, 1988
PRO,LOC,POL,MOL "Tepler I &: AJHG, 45, 761-765, 1989

KEY

imm, img, recp, mfd

CLA

coding, basic

LOC

01 q23

MIM

MIM: 147140

SYN

FCER1A FCE1A

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