Gene: [11q13/IGER] IgE responsiveness (atopic); atopic hypersensitivity (allergic asthma and rhinitis, liability 2); [APY ]

COM

[1] As for atopies (principally allergic asthma and rhinitis), the MIM and GEM Catalogues mention, in addition to this marker, two others, the genetic and functional relationships between them remaining unclear (GEM:01q23/IGHER1A; GEM:13q14/IGHEE).
[2] MIM describes the markers APY (this locus) and IGEL (GEM:13q14/IGHEE) under the same number, although it indicates that they are determined by different genes in Chrs 11 and 13."

REF

LIN,LOC "Amelung PJ &: Clin Exp Allergy, 22, 1077-1084, 1992
LIN,LOC "Coleman R &: Lancet, 341, 1121-1122, 1993
LIN,PAT,FOG "Cookson WO &: Lancet, 340, N8816, 381-384, 1992
LOC,LIN,MOL "Cookson WO &: CCG, 51, (HGM10), 979, 1989a
LIN,PAT,FOG "Cookson WO &: Lancet, 1, 1292-1295, 1989b
FOG "Cookson WO, Hopkin: Lancet, 1, 86-88, 1988
LIN,LOC "Hizawa N &: J Med Genet, 32, 363-369, 1995
LIN,LOC "Hizawa N &: Clin Exp Allergy, 22, 1065-1069, 1992
LIN,LOC "Lympany P &: Clin Exp Allergy, 22, 1085-1092, 1992a
LIN,LOC "Lympany P &: J Allergy Clin Immunol, 89, 619-628, 1992b
LIN,LOC "Moffatt MF &: Clin Exp Allergy, 22, 1046-1051, 1992
LIN,LOC "Rich SS &: Clin Exp Allergy, 22, 1070-1076, 1992
LIN,LOC "Sandford AJ &: Lancet, 341, 332-334, 1993
LIN,LOC "Shirakawa T &: Clin Genet, 46, 228-232, 1994
LIN,LOC "Shirakawa T &: CCG, 58, 1970-1971, 1991
LIN,LOC "Young RP &: J Med Genet, 29, 236-238, 1992
LIN,LOC "Young RP &: CCG, 58, 1974-1975, 1991

KEY

imm, mfd

CLA

unknown, basic

LOC

11 q13

MIM

MIM: 147050

SYN

APY

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