Gene: [13q14/IGHEE] immunoglobulin-E expression regulator (basal serum level); atopic IgE responsiveness (allergic asthma and rhinitis?); [IGHER IGEL ]
|
COM |
[1] Symbol IGHER (or IGER), which is adopted in MIM and some other
sources, does not fit well this gene, because the character R at the
end of symbol means (in terms of the HGM denotation) that product of
the gene is a receptor. This is not established for this gene yet;
therefore, the GEM catalogue has adopted symbol IGHEE.
[2] The OMIM catalogue describes markers APY# (APY2*) and IGEL# (IGHEE*) under the same number, although it indicates that they are determined by different genes in chrs 11 and 13." |
|
HET |
MIM and GDB mention two additional markers concerning atopies (bronchial asthma and hay fever or allergic rhinitis): GEM:01q23/IGHER1A and GEM:11q13/IGER. Their genetic and functional relationships remain unclear." |
|
REF |
HIS,FOG "Bazaral M &: J Allergy Clin Immunol, 54, N5, 288-304, 1974 HIS,FOG "Bazaral M &: J Immunol, 107, N3, 794-801, 1971 HIS,FOG "Bias &: AJHG, 25, 16A, 1973 FOG,PHE "Blumenthal &: Am J Med Genet, 10, 219-228, 1981 REV,FUN,PAT "Capron, Dessaint: Ann d'Immunol, 132, (C, N1), 3-8, 1981 REV,FUN,PAT "Collins AM: Lancet, 1, (2 Apr), 734-737, 1988 FOG,PHE "Cookson, Hopkin: Lancet, 1, 86-88, 1988 LIN,LOC "Eiberg &: CCG, 40, (HGM8), 622, 1985 FOG,PHE "Gerrard &: AJHG, 30, 46-58, 1978 FOG,PHE "Hasstedt &: Am J Med Genet, 14, 61-66, 1983 FOG,PHE "Hopkin JM: Clin Exp Allergy, 19, 263-265, 1989 REV,FUN,PAT "Katz DH: Immunology, 41, 1-24, 1980 HIS,FOG "Marsh &: PNAS, 71, N9, 3588-3592, 1974 LIN,LOC "Meyers DA &: Am J Med Genet, 16, 575-581, 1983 FOG,PHE "Meyers DA &: Hum Hered, 32, 15-23, 1982 HIS,FOG "Opree W &: Acta Allergol, 27, N4, 247-256, 1972 FOG,PHE "Rao &: AJHG, 32, 620-625, 1980 FOG,PHE "Sistonen &: Hum Hered, 30, 155-158, 1980 FOG,PHE "Trubnikov VI &: Genetika, 17, N12, 2220-2227, 1981 |
|
KEY |
imm, mfd |
|
CLA |
unknown, basic |
|
LOC |
13 q14 |
|
MIM |
MIM: 147050? |
|
SYN |
IGHER IGEL |
