Gene: [19p133/IGHER2] immunoglobulin E Fc-receptor II (low-affinity; antigen CD23); atopy 4? (allergic asthma and hay fever, liability 4); [CD23A FCE2 ]
|
MOP |
Two receptors for IgE Fc domain are identified: the high-affinity one (receptor 1, FCE1A) and the low-affinity one (receptor 2, FCE2). Receptor 1 is supposed to be formed by three subunits; for more details, see GEM:01q23/IGHER1A. The gene for receptor 2 is cloned, and its coding region is sequenced. The soluble form of the receptor has MM 43-45 kD. This protein shares homology with animal lectins." |
|
FAG |
The gene for alpha subunit is mapped to chr 1q (GEM:01q23/IGHER1A). On other genes, see GEM:01q23/IGHER1A." |
|
PAT |
MIM and HGM mention two other markers (besides IGHER1A locus) in connection with atopies (mainly bronchial asthma and hay fever or allergic rhinitis): GEM:11q13/IGER and GEM:13q14/IGHEE. Genetic and functional relationships between these markers remain unclear. It is possible that genes for receptor 1 subunits and for receptor 2 are related with those atopies, which clinical genetic heterogeneity was demonstrated previously with formal genetic methods. Therefore, the GEM catalogue has included at least four types of atopy liability." |
|
REF |
EXP,MEB,PAT "Bujanovski-Veber &: Immunology, 66, N4, 505-511, 1989 REV,FUN,EXP,MOP "Delespesse &: Int Arch Allerg Immunol, 88, 18-22, 1989 EXP,MEB,PAT "Hivroz &: Eur J Immunol, 19, N6, 1025-1030, 1989 PRO,COD,SEQ,EVO "Ikuta K &: PNAS, 84, N3, 819-823, 1987 MEB,FUN "Kikutani H &: Cell, 47, 657-662, 1986 EXP,MEB,PAT "Nosoda &: J Immunol, 143, N1, 147-153, 1989 LOC,CYG "Wendel-Hansen V &: Somat Cell Mol Genet, 16, N3, 283-285, 1990 |
|
KEY |
imm, img, recp, mfd, cyk |
|
CLA |
coding, basic |
|
LOC |
19 p13.3 |
|
MIM |
MIM: 151445 |
|
SYN |
CD23A FCE2 |
