Gene: [14q112/CTLA1] cytotoxic T-lymphocyte-associated serine esterase 1 (CSP-B); granzyme B (cathepsin G-like enzyme 1); T cell/natural killer cells serine esterase 1;
MAP | Loci:
GEM:14q112/CTSG; GEM:14q112/CTSGL2. [1] CTLA1-CTSGL2-CTSG [app.50kb](Hanson-1990). Com. All the three genes belong to the tandem cluster of cathepsin G-like serine proteases." |
FAG | Three genes for serine proteases expressed in T killers are mapped in the human genome: CTLA1, GEM:05q1/CTLA3, and GEM:02q33/CTLA4." |
FUN | Preferential cleavage: asp-|-xaa >> asn-|-xaa > met-|-xaa, ser-|-xaa. |
REL | GEM:05q1/CTLA3; GEM:02q33/CTLA4; GEM:02q31/IL17. See also GEM:14q112/CTSGL2; GEM:00.0/GZMK; GEM:19p133/GZMM." |
REF | PRO,GEN,LIN,FAG,MAF
"Hanson RD &: PNAS, 87, N3, 960-963, 1990 PRO,LOC,EAG,HUM,MOU "Harper K &: Immunogenetics, 28, 439-444, 1988 PRO,GEN,LOC "Klein JL &: Genomics, 5, 110-117, 1989 LOC,LIN,MOL "Lin CC &: CCG, 53, N2-3, 169-171, 1990 EXP "Schmid J, Weissman: J Immunol, 139, 250-256, 1987 PRO,COD,SEQ,EXP,EVO,HUM,MOU "Trapani JA &: PNAS, 85, N18, 6924-6928, 1988 |
SWI | SWISSPROT: P10144 |
KEY | imm, pep |
CLA | coding, basic |
LOC | 14 q11.2 |
MIM | MIM: 123910 |
EZN | ENZYME: 3.4.21.79 |
